saffron, also known as Za’faran, is a spice derived from the Crocus sativus plant. Alluding to its yellow color and high cost, saffron is often referred to as the Golden Spice. saffron has been used a seasoning in food and as a coloring agent for over 4 millennia. Today, over 90% of the worlds saffron supply stems from Iran [R].
saffron is composed of a variety of chemical compounds that give rise to its taste, color and health benefits. Historically, saffron was used in traditional medicine to treat a variety of ailments including:
- Anxiety relief
- Treatment of premenstrual syndrome (PMS)
- Insulin resistance
- Neurodegenerative disorders
- Learning disabilities
Although the role that saffron plays in mediating these benefits has not been completely understood, saffron has been proven to improve certain conditions like sexual dysfunction, depression, premenstrual syndrome (PMS), and Alzheimer’s, among others [R, R].
Formulations of saffron
To observe health improvements from saffron, doses much higher (30 to 50 mg) than that found in food are required. Today, a number of saffron formulations exist containing doses that have been proven to have a positive outcome. These include [R]:
- Itch cream
- Scar removal cream
- Infusion into a tea
The dose of saffron and its active components may vary amongst formulations, or even between different manufacturers of the same preparation. Therefore, the health benefits observed may differ depending on the quality of the plant, the dose in each formulation or the constituents overall [R].
Nutritional Values of saffron
Carbohydrates – 1.37 grams
Fat – 0.12 grams
Proteins – 0.24 grams
- Vitamin C: 1.7 mg
- Vitamin B9: .002 ug
- Vitamin B6: 0.02 mg
- Vitamin B3: 0.03 mg
- Vitamin B2: 0.01 mg
- Iron: 0.23 mg
- Manganese: 0.6 mg
- Magnesium: 6 mg
- Copper: 0.01 mg
- Phosphorous: 5 mg
- Potassium: 36 mg
- Kaempferol – 4.3 mg
Chemical Composition of saffron
Carotenoids: A group of compounds found in plants that are responsible for producing color in leaves and petals [R].
- Crocetin and crocin give saffron its yellowish-red color.
- Other carotenoids of importance include lycopene, zeaxanthin, and beta-carotene
Volatile oils: The aromatic oils extracted from plants, often known as essential oils [R].
- Picrocrocin is responsible for the bitter taste of saffron
- Safranal produces the odor and aroma of saffron
- Type 2 diabetes
- Heart disorders
- Cosmetics (to delay aging effects on the body)
Mechanism of Action
The chemical components of saffron are responsible for its health enhancing effects. However, given a large number of chemicals present and the diverse therapeutic benefits that it exhibits, it is not entirely clear how saffron exerts its therapeutic effects [R].
It also acts as an antioxidant, picking up free radicals that could cause damage to proteins and DNA in cells. saffron inhibits the buildup of the amyloid-beta protein, the main cause of Alzheimer’s disease [R].
Crocetin is thought to increase serotonin levels in the brain, which might explain its antidepressant and anxiety-relieving effects [R].
- Stimulates beta 2 receptors: Adrenergic receptors that increase blood flow and heart rate. Stimulation mimics the effects of noradrenaline and adrenaline.
- Inhibits histamine 1 receptors: Blocks the activity of histamine.
- Inhibits muscarinic receptors: Blocks the activity of acetylcholine.
- Stimulates GABAa receptors: Mimics GABA, further increasing the anxiety-relieving effects.
Health Benefits of saffron
1) saffron Is an Antioxidant
saffron’s antioxidant effects may delay the effects of aging and protect the skin from sunlight damage that could potentially lead to cancer. As a result, saffron is often found as an ingredient in sunscreens and lotions [R].
2) saffron Can Improve Immune Function
saffron also increased white blood cell count without affecting the levels of other blood cells. This means that it can selectively enhance immunity without increasing the risk of other blood-related complications [R].
3) saffron Can Boost Energy Levels
In a study (DB-RCT) of 28 healthy men, saffron supplementation for 10 days increased muscle strength and improved reaction time. This is likely due to improved mitochondrial function in the cell (antioxidant activity) and function of the region of the brain responsible for reacting to visual and auditory stimulus (motor cortex) [R].
4) saffron Can Reduce Symptoms of PMS
In a group of 35 women, exposure to the odor of saffron for 20 minutes significantly reduced symptoms of PMS and improved irregular periods. This effect occurred through a reduction of the stress hormone, cortisol [R].
5) saffron May Improve Heart Function
saffron may improve heart function by increasing the pumping capacity of the heart ventricles. This may be due to the presence of kaempferol, a molecule that reduces the incidence of heart attacks and coronary heart disease [R, R, R].
In rats suffering from heart attacks, saffron protected the heart from toxicity caused by taking certain drugs. This may be mediated by its antioxidant effects on the heart tissue, which assist in removing damage caused by toxins [R, R].
6) saffron Can Improve Sexual Function
Another study (DB-RCT) in 25 diabetic men with erectile dysfunction (a common symptom in diabetes) found that saffron gel significantly improved sexual function and increased the frequency of erections [R].
Certain medications can diminish sexual drive and cause pain during sex, like antidepressants. In a study (DB-RCT) of 38 women, saffron supplemented for 4 weeks improved sexual drive and reduced pain associated with sex. saffron also increased lubrication, which helped minimize pain during sex [R].
7) saffron Can Improve Mood Disorders
In another study (DB-RCT) of 40 women with postpartum depression, saffron supplementation for 6 weeks was more effective in treating mild to moderate depression than the common antidepressant Prozac [R].
saffron can also relieve anxiety in mice. One study in mice found that saffron extract reduced anxiety-like behaviors (elevated plus maze test) and increased sleeping time. This indicates that saffron may be effective in treating insomnia and other sleep-related disorders [R].
Similar improvements in depressive symptoms were seen in 61 patients (DB-RCT) with schizophrenia given saffron extract for 12 weeks. saffron was well tolerated and is considered safe to use, but more research is needed to determine if saffron is as effective as the current therapies used in treating schizophrenia [R, R,].
8) saffron May Reduce Blood Pressure
saffron may be effective for individuals with hypertension, but this claim still needs to be evaluated in humans who suffer from this condition.
9) saffron May Combat Cancer
Crocetin can selectively target cancer cells and kill them. It does this by inhibiting the production of cancerous proteins and increasing cell death (apoptosis) [R].
These results have yet to be verified in humans.
10) saffron Is Beneficial for Alzheimer’s
Similarly, injection of crocin into rats improved cognitive ability and memory [R].
saffron may in part improve dementia by inhibiting an enzyme that breaks down acetylcholine (acetylcholinesterase). This enzyme is a current target of donepezil, one of the only approved medications used to treat mild to moderate Alzheimer’s disorder [R].
11) saffron May Promote Weight Loss
- Reducing fat absorption
- Reducing digestion
- Reducing calorie intake by lowering appetite
- Improving glucose and fat utilization for energy
12) saffron and Pregnancy
However, although saffron shows some benefits in pregnant women, increased rates of miscarriages were observed in 40 pregnant women who work in saffron fields. This may be associated with saffron toxicity during chronic exposure [R].
13) saffron Is Anti-inflammatory
saffron extract supplementation reduces the levels of inflammatory molecules (TNF-alpha, interleukin 1beta) released in response to cellular stress. It can also decrease the molecules (via increases in histone deacetylase) that are causing damage and stress to the internal compartments of a cell [R].
14) saffron Protects the Brain
- Reducing inflammation in the brain
- Regulating levels of neurotransmitters
- Antioxidant activity that reduces damage to the brain
- Protecting the brain from injury
- Preventing cell death in the brain (apoptosis)
15) saffron May Help Heal Wounds
When tested in cells, the saffron extract was able to increase levels of molecules that promote skin growth and regeneration (VEGF). Similarly, saffron reduced inflammatory molecules, which in turn promoted wound healing. This effect may prove beneficial in wound recovery and in the cosmetics industry [R].
16) saffron May Improve Bone Health
After menopause, many women suffer from issues with bone health resulting in conditions like arthritis and osteoporosis. This occurs due to changes in hormone (estrogen) levels that are responsible for maintaining bone health.
In a rat model of osteoporosis, saffron extract given for 16 weeks was able to prevent the progression of osteoporosis. This was likely mediated by an increase in estrogen levels, which promotes healthy bone cell growth [R, R].
17) saffron May Benefit Asthma
Historically, saffron has been used in traditional medicine to treat spasms in the lungs and asthma attacks.
saffron may exert this benefit by relaxing the smooth muscles of the lungs, as seen in mice. However, the exact target of saffron in the lungs is unknown and clinical trials are needed to prove its efficacy in humans [R].
18) saffron May Benefit Digestion
19) saffron Is a Painkiller
Certain types of pain cannot be addressed using common painkillers, like neuropathic pain. Neuropathic pain occurs within the nerves and is a symptom of certain conditions like fibromyalgia and diabetes and can occur from injuries.
This suggests that saffron may play a role in mediating certain types of pain, but this has yet to be confirmed in humans.
20) saffron May Improve Liver Health
This effect is mediated by 3 possible ways [R]:
- Inhibiting certain enzymes that create toxic byproducts
- Protecting against oxidative stress
- Regulating the cell structure of the liver (hepatic membrane)
21) saffron May Prevent Seizures
saffron has been used in traditional medicine for its ability to prevent seizures (anticonvulsant properties) for a long time. When tested in both rats and mice, saffron use was able to suppress seizures at doses above 400 mg/kg [R].
In epileptic mice, saffron’s active ingredient safranal was able to suppress seizures. This is due to binding at the GABA A receptor, similar to the way benzodiazepine drugs (Xanax, Valium) are successful in preventing certain types of seizures (absence seizures) [R].
22) saffron May Benefit Diabetes
In muscle cells, saffron increased glucose utilization and the uptake of glucose from the bloodstream. When given alongside insulin, saffron enhanced the activities of insulin and the responsiveness of the cell to insulin [R].
23) saffron May Improve Eyesight
saffron extract supplementation was able to improve blood flow to the eyes and therefore, improve vision in animals with age-related visual decline. This effect is mediated by crocin, which dilates the vessels carrying blood to the eyes [R].
Side Effects of saffron Supplementation
- Dry mouth
- Change in appetite
- A headache
Pregnant women should not take saffron (unless they consult a doctor), regardless of the potential benefits that have been demonstrated in earlier studies. Enough evidence indicates that saffron may pose a risk to the fetus and the mother [R].
Limitations and Caveats
Although extensive research has been conducted on saffron, a few caveats exist that limit the reliability of these studies:
- Different studies use various parts of the Crocus sativus plant; petals, extracts, isolated crocin or safranal, supplements, or gels. The chemical composition of the different parts of the plant vary and thus, the full profile of health benefits may be limited to one part of the plant.
- Most of the clinical studies on the health benefits of saffron were undertaken in Iran. Patients with different genetic backgrounds may respond differently to saffron. Therefore, global wide-scale studies are required to accurately determine if saffron has significant benefits for people of different backgrounds.
- Many of the doses used are much higher than the dose of saffron obtained from foods.
- Cooking with saffron may break down the active chemicals, rendering them ineffective for treating certain conditions. Therefore, to see the full benefits of saffron it is recommended that this substance is taken in supplemental form.
- saffron manufactured by different companies may have different chemical compositions and therefore, the benefits cannot always be guaranteed unless purchased from a reliable source (see below for where we recommend buying saffron).
Adulteration of saffron
Due to the high price of saffron, vendors often sell adulterated versions of this spice. This adulteration can range from substituting a completely different plant such as safflower or marigold flowers, to adding dyes to recover the color of already used saffron. It is not uncommon to see other parts of the Crocus sativus plant used in place of the stigmas (the part that constitutes saffron) (R).
However, this does not mean that supplementing with saffron while taking medications is safe.
saffron is presumed to have activity at the serotonin reuptake pump, acting as an inhibitor of this protein (SSRI). If you are taking an antidepressant that increases serotonin levels, consult your doctor before supplementing with saffron. You may be at risk of developing serotonin syndrome, which is a life-threatening condition.
“Taking to control cravings. Found it does suppress appetite and boosts mood. Not a miracle drug though.”
“I found after a few weeks it definitely helped me control my appetite. I did not look at side effects until after this time and found out the odd dizziness and nausea I was feeling was definitely a side effect. The dizziness was actually frightening because it was severe.”
“I had a horrible migraine-like headache and dizziness after about 4 weeks of use. I was nauseous and overall malice feeling.”